The SearchVoat Forum

2017Fallout wrote: ↑Thu Jan 14, 2021 8:44 am Its going to be real awkward when all thats left is us and our overlords. Staring at each other like some showdown in a Clint Eastwood movie.

Both processes were at play as an unfortunate situation unfolded in the 1960s, according to Graham. Researchers at the time were pursuing a vaccine against RSV, the leading cause of severe respiratory illness in infants. In trials of one vaccine candidate, several children who received the vaccine developed a serious illness when infected with the natural virus.

When SARS, also a coronavirus, appeared in China and spread globally nearly two decades ago, Hotez was among researchers who began investigating a potential vaccine. In early tests of his candidate, he witnessed how immune cells of vaccinated animals attacked lung tissue, in much the same way that the RSV vaccine had resulted in immune cells attacking kids’ lungs. “I thought, ‘Oh crap,’” he recalls, noting his initial fear that a safe vaccine may again not be possible.

But his team revised their approach. Instead of producing the whole spike protein of the virus, they built just a tiny piece of it—the piece that attaches to human cells, called the receptor-binding domain. Subsequent animal tests showed that this strategy did provide the desired protection without the unwanted immune enhancement.

Lets_talk wrote: ↑Sun Jan 17, 2021 4:17 pm I did some digging; it seems like the issue this lady is pointing out was solved when creating SARS vaccines by leaving out part of the viral spike protein: https://www.pnas.org/content/117/15/8218 (read 'Rogue Responses')

So it shouldn't be a problem with the covid vaccine. Wouldn't it have shown up in the trials if it was, anyway? All it would take would be one patient getting exposed to the virus after vaccination.

Both processes were at play as an unfortunate situation unfolded in the 1960s, according to Graham. Researchers at the time were pursuing a vaccine against RSV, the leading cause of severe respiratory illness in infants. In trials of one vaccine candidate, several children who received the vaccine developed a serious illness when infected with the natural virus.

When SARS, also a coronavirus, appeared in China and spread globally nearly two decades ago, Hotez was among researchers who began investigating a potential vaccine. In early tests of his candidate, he witnessed how immune cells of vaccinated animals attacked lung tissue, in much the same way that the RSV vaccine had resulted in immune cells attacking kids’ lungs. “I thought, ‘Oh crap,’” he recalls, noting his initial fear that a safe vaccine may again not be possible.

But his team revised their approach. Instead of producing the whole spike protein of the virus, they built just a tiny piece of it—the piece that attaches to human cells, called the receptor-binding domain. Subsequent animal tests showed that this strategy did provide the desired protection without the unwanted immune enhancement.